Depends on what you're asking here
The whole "50 different genders" thing is excessive special snowflake-ism
But there's no reason not to believe that differences in brain developments or hormones or whatever could cause someone to feel different than the genitals they have, especially when there's a
legit diagnosis for more progressed (not sure if that's the right word here but I can't think of a better one) cases. Refusing to accept that someone could have a snake, yet feel female, is just crying "wahh i refuse to learn new things"
I know your title is addressing the former, but there's always people (MoltenKitten) that throw the latter in there as well
if you see some guy walking around saying 'I'm a fox' are you going to treat him like a fox just to make him feel good? these people don't need special treatment, they need special help. it doesn't harm anybody directly but it sure as hell harms society if people accept this.
This is a terrible brown townogy because both male and female are actual things a person can be, all it takes is a hormone change in the womb, but there's no hormone that can turn a human into a fox