Def, but just a warning; make sure it matches with your monitor's aspect ratio or else some tablet area would be wasted.
I doubt it. at least with wacom tablets, it uses the whole space, regardless of screen size
one time when I was using my bamboo, and I was also using two screens, I was getting frustrated for a bit, until I realized that the reason I moved way too fast horizontally was because it was including the second monitor as well