If drugs had nasty side effects people would still use the drugs as long as they have incredibly high bonuses.
If you don't want the terrible side effects why not just get the perk that makes you immune to all side effects? That's what the loving perk is for.
The drugs have been made in a way so that they
can add the perk without making stuff OP. Note that if your chem system was added in the game this wouldn't be a thing. As a matter of fact, chems would stop suddenly being useful in most situations, and you'd only actually find them useful like 1% of the time you would normally would.
This is not good design. Unless you are adding a feature for the
sole purpose of adding extra insignificant details to make the game look more comprehensive, then the features you have should
actually be beneficial to the gameplay. Yeah people would still use them but they wouldn't use them half as much, so what's the damn point? With major items and system like the chem system you want players to use them more often because they add a cool dynamic to the gameplay, instead of just mindless frustration. I sure as hell know that if I had to luggage around a debuff for 7 loving in-game days because I dare boost my accuracy or some bullstuff then I would just sell the stuff off, kinda like what your post said before you edited it.
Also the chems in Fallout 4 are better because the main characters screams crazy stuff when he injects psycho which is loving hilarious so forget you and your archaic dinosaur chems
this game is teaching kids that there are no bad side effects from drugs
You even loving trying anymore bro?